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Image Search Results
Journal: Scientific Reports
Article Title: Chronic intermittent hypoxia promotes myocardial ischemia-related ventricular arrhythmias and sudden cardiac death
doi: 10.1038/s41598-018-21064-y
Figure Lengend Snippet: Intermittent hypoxia (IH) enhances myocardial ischemia-related lethal ventricular arrhythmias. ( A ) Incidence of lethal arrhythmias occurring during regional myocardial ischemia in rats exposed to 14-days of normoxia (N) or IH. ( B ) Incidence of both reversible and irreversible ventricular fibrillation (VF) during ischemia. n = 27 and 24 in N and IH groups, respectively. ( C ) Representative recording showing ischemia-induced SCD (irreversible VF) in a rat submitted to IH. The upper tracing represents arterial blood pressure (mmHg), and the lower tracing ECG lead II with characteristic ST-segment elevation (mV). ( D ) Incidence of VF occurring during a 30-min regional ischemia in isolated hearts of rats exposed to N or IH. n = 24 and 29 in N and IH group, respectively. *p < 0.05 vs. N. **p < 0.01 vs. N.
Article Snippet: Baseline ECG recordings were analyzed using a
Techniques: Isolation
Journal: Scientific Reports
Article Title: Chronic intermittent hypoxia promotes myocardial ischemia-related ventricular arrhythmias and sudden cardiac death
doi: 10.1038/s41598-018-21064-y
Figure Lengend Snippet: Intermittent hypoxia (IH) promotes heterogeneity of ventricular repolarization, increases the transmural action potential gradient and alters the transmural expression of Ca 2+ channels. ( A ) Typical ECG lead II recorded in anesthetized rats, with details of P wave, QRS complex, T wave, QT interval and Tpeak-Tend intervals. IH induced a significant increase in QTc ( B ) and Tpeak-Tend intervals (in milliseconds: ms) ( C ) compared to normoxia (N). n = 14 per group. ( D ) IH exposure induced a significant increase in endocardial APD50, but not in epicardial APD50, compared to normoxia (N). n = 10 and 9 in N and IH group, respectively. ( E ) Representative monophasic action potential (MAP) recording showing measurement of action potential duration at 50% (APD50) and 90% of repolarization. ( F ) Epicardial and ( G ) endocardial mRNA levels of Ca v 1.2 ( Cacnac1c ), Ca v 1.3 ( Cacnac1d ) and TRPC1/4/6 ( Trpc1/4/6 ) in rats exposed to normoxia (N) or IH. n = 6 per group. Data are expressed as mean +/− SEM. *p < 0.05 vs. N. **p < 0.01 vs. N. ***p < 0.001 vs. N.
Article Snippet: Baseline ECG recordings were analyzed using a
Techniques: Expressing